Thyroxine-Binding Globulin; Human

General description

M.W. 54,000-64,000.

Native, human thyroxine-binding globulin. Liver glycoprotein and a major thyroid hormone carrier in serum. Exhibits high sequence similarity with α₁-antitrypsin. Its affinity for the hormone is thought to be temperature-sensitive.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Miura, Y., et al. 1993. Endocrinol. J. 40, 127.Janssen, O.E., et al. 1992. J. Biol. Chem.267, 13998.

Packaging

250 µg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In 140 mM NaCl, 10 mM Tris, 0.1% NaN₃, pH 8.0. Sterile-filtered.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Standard Handling (A)